9 Reasons to Include Ashwagandha in Your Health Regimen | Dr. Joseph Mercola

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Source: Mercola.com

Story at-a-glance

  • Known as Rasayana in Ayurveda, ashwagandha is an adaptogenic herb that enhances your body’s ability to withstand stress and is considered to be a rejuvenator
  • Ashwagandha contains compounds known as withanolides, which have not only antioxidant and anti-stress activities but also enhance immunity, protect the heart and offer neuroprotective, hypoglycemic, and anti-tumor effects
  • Ashwagandha has notable benefits for relieving stress and anxiety and supporting brain health, such that taking ashwagandha for 90 days improved memory and focus
  • Withanolides have also been shown to suppress pathways responsible for several inflammation-based illnesses, including arthritis, asthma, high blood pressure, osteoporosis, and cancer

Ashwagandha (Withania somnifera) is an herb that’s been used in Ayurvedic medicine for thousands of years. Known as Rasayana in Ayurveda, ashwagandha is an adaptogenic herb that enhances your body’s ability to withstand stress and is considered to be a rejuvenator.1 According to Ayurveda, ashwagandha is also known as:2

  • Balya — increases strength
  • Brusya — Sexual performance enhancer
  • Vajikari — Spermatogenic
  • Kamarupini — Libido enhancing
  • Pustida — Nourishing

Also known as Indian ginseng or winter cherry, ashwagandha contains compounds known as withanolides, which have not only antioxidant and anti-stress activities but also enhance immunity, protect the heart and offer neuroprotective, hypoglycemic, and anti-tumor effects.3 Its name comes from the Sanskrit word “ashwa,” or horse because its root smells like horse urine and gives you the power of a horse when consumed.4

Nine Reasons to Consume Ashwagandha

In addition to withanolides, ashwagandha contains phenolic acids, alkaloids, saponins, and tannins, which offer a wide variety of pharmacological activities. Together, ashwagandha and its bioactive compounds may benefit diseases such as arthritis, impotence, amnesia, anxiety, and more. Ayurvedic doctor Dixa Bhavsar explained on social media:5,6

“This miracle herb has taken the medical world by storm (especially during #covid). And for good reason. Ashwagandha (Indian ginseng) is immune boosting, anti-inflammatory, sleep inducing, anticonvulsant, anti-stress, and antibacterial properties, this herb is like the one-stop shop for all ailments.”

Why else might you want to consider ashwagandha?

1. Relieve Stress and Anxiety — In a study of 125 adults who took ashwagandha or placebo daily for 90 days, those who took ashwagandha had lower serum cortisol levels — a measure of stress — and higher scores on a happiness questionnaire, “suggesting significantly lower stress levels and significantly better psychological well-being and sleep quality.”7

Another study involving 64 individuals who had a history of chronic stress evaluated the effectiveness of a full-spectrum extract of ashwagandha root to help reduce stress and anxiety. Those in the study group took 300 milligrams (mg) of ashwagandha root twice a day for 60 days.

Analysis of the data revealed a significant reduction in stress assessment at the end of 60 days when compared to the placebo group. People taking ashwagandha also had substantially lower serum cortisol levels.8 According to the study, which was published in the Indian Journal of Psychological Medicine:9

“The findings of this study suggest that a high-concentration full-spectrum Ashwagandha root extract safely and effectively improves an individual's resistance towards stress and thereby improves self-assessed quality of life.”

2. Improve Cognitive Function — Ashwagandha has notable benefits for brain health, such that taking ashwagandha for 90 days improved memory and focus in cognitively sound adults between the ages of 20 and 55.10

In another study of adults with mild cognitive impairment, eight weeks of ashwagandha supplementation twice daily led to significantly greater improvements in immediate and general memory, executive function, sustained attention, and information-processing speed compared to placebo.11

The herb was also found to improve aspects of cognition, including verbal working memory, response time, and social cognition response in people with bipolar disorder.12

3. Better Sleep — If you’re looking for a sound night’s rest, sleep hygiene should be your go-to response, tending to things like eliminating light in your bedroom, turning off electronics well before bedtime, and going to bed and waking at approximately the same time each day. However, ashwagandha maybe provides a natural complement to these strategies.

In an analysis of five randomized controlled trials containing 400 participants,13 ashwagandha extracts had a beneficial effect in improving sleep. The benefits were most pronounced in those with insomnia, those who took a dosage of 600 mg per day or more and used ashwagandha for at least eight weeks.

As a pleasant “side effect,” those who took ashwagandha had improved mental alertness when they woke up, along with less anxiety. A 2020 study also tested ashwagandha for its ability to promote sleep. Based on the results, the researchers believe the herb could be an alternative treatment for insomnia.14 It found that ashwagandha root extract improved sleep quality and helped in managing insomnia.

While both healthy subjects and people with insomnia reported significant improvement in sleep parameters from ashwagandha, the improvement was more significant in those with insomnia.

4. Boost Immune Function — Withanolides in ashwagandha have immunomodulating properties that can either stimulate or suppress your immune system to help fight infections, cancer, and other diseases.15 As explained in the Journal of Clinical Medicine:16

“Ashwagandha (Withania somnifera or WS) which is mentioned in the Rasayana group of medications in the Ayurveda tradition of India has been extensively investigated as an immunomodulatory agent.

The components in WS mainly withanolide glycosides exert their immunomodulatory action by mobilizing and activating macrophages and induce proliferation in murine splenocytes. This effect has been suggested to be the idea of its use as a Rasayana in Ayurveda.”

In a randomized placebo-controlled double-blinded study, subjects received either 60 mg of ashwagandha extract or a placebo. The extract significantly improved the immune profile by modulating both the innate and adaptive immune systems. According to the researchers, the effects were so impressive that “[b]oosting the immune system of people at risk of infection and during widespread infections can be targeted with WS extract.”17

Withaferin A (WFA), found in ashwagandha, has also been found by at least two independent research groups to bind to the viral spike protein in SARS-CoV-2. By interfering with the spike protein, as well as not affecting ACE2 expression in the lungs, researchers concluded it “demonstrates real potential as a therapeutic agent to treat or prevent the spread of COVID-19.”18

5. Anti-Inflammatory Effects — Ashwagandha and its withanolides are powerful anti-inflammatories. The herb suppresses inflammatory responses in microglial cells, which are found in the central nervous system, by “simultaneously down-regulating the NF-kB and upregulating the Nrf2 pathways.”19

Animal studies also suggest that ashwagandha produces an anti-inflammatory response that’s comparable to the anti-inflammatory drug hydrocortisone sodium succinate.20 Withanolides have also been shown21 to suppress pathways responsible for several inflammation-based illnesses, including arthritis, asthma, high blood pressure, osteoporosis22, and cancer.

6. Anticancer Potential — Ashwagandha has been found to interfere with the growth of new cancer cells while leaving normal cells untouched, while also helping to induce programmed death of cells and sensitize cancer cells to apoptosis.23

Multiple studies have found anticancer effects from both ashwagandha and its active component WFA,24 for a variety of cancers including prostate, leukemia, breast, pancreatic, glioblastoma multiforme, and colorectal. At least two uses for the herb and its compounds were suggested by a review published in the International Journal of Molecular Sciences:25

“First, given the safety record of WS [Withania somnifera], it can be used as an adjunct therapy that can aid in reducing the adverse effects associated with radio and chemotherapy due to its anti-inflammatory properties.

Second, WS can also be combined with other conventional therapies such as chemotherapies to synergize and potentiate the effects due to radiotherapy and chemotherapy due to its ability to aid in radio- and chemosensitization, respectively. Taken together, all evidence to date indicate the potential of WS or WFA in cancer management.”

7. Arthritis Benefits — Because of ashwagandha’s anti-inflammatory properties, it’s often used in managing arthritis. When researchers analyzed 77 registered clinical trials in India to look for evidence of ashwagandha’s anti-arthritic properties,26 they found “a dosage of 6 gm in powder form or extracts in tablets, or 500- to 1000-mg capsule consumed for a duration of 8 to 12 weeks may be useful in managing symptoms of arthritis in patients.”

Traditionally, ashwagandha is noted in Ayurvedic manuscripts as being an effective remedy for rheumatoid arthritis (Amavata) and osteoarthritis (Sandhi-gata Vata).27 Another review article noted:28

“Patients of rheumatoid arthritis receiving Ashwagandha root powder showed excellent response. Their pain and swelling completely disappeared. A double-blind placebo-controlled study, combining Ashwagandha, turmeric and zinc, showed significant improvement in pain and inflammation.”

8. Anti-Obesity Properties — Ashwagandha’s WFA also has anti-obesity properties, helping to enhance energy expenditure and ameliorate obesity by triggering mitochondrial biogenesis and browning-related gene expression.29 Separate research also suggests WFA may protect against diet-induced obesity by attenuating oxidative stress, inflammation, and insulin resistance.30

9. Sexual and Reproductive Health Benefits — In men struggling with infertility, ashwagandha has been shown to balance their luteinizing hormone,31 which controls reproductive organ function in both men and women. Ashwagandha can also help boost testosterone levels in men,32 which can have a beneficial effect on libido and sexual performance.

It's also been shown to improve the quality of semen in infertile men, in part by inhibiting reactive oxygen species.33 In otherwise healthy women, ashwagandha has been shown to improve arousal, lubrication, orgasm, and overall sexual satisfaction.34 Ashwagandha root extract may also help to relieve mild to moderate symptoms of menopause in perimenopausal women.35

Work With an Integrative Health Care Practitioner

When using powerful nutraceuticals like ashwagandha, working with an Ayurvedic or integrative health care practitioner can help ensure you receive optimal benefits. Depending on your health status and other factors, for instance, it can have differing effects. Bhavsar explained:36

“The leaves of ashwagandha helps in losing weight. Yes, you heard me right. Mostly I see people getting confused when they hear its useful for weight gain & weight loss at the same time. So this is just to clear the confusion. Its dosage depends on the patient’s condition, prognosis & the mind-body type.”

While ashwagandha is generally safe, well-tolerated, and nontoxic, it shouldn’t be used by pregnant women, breastfeeding women, or people taking sedatives. Making sure you're getting a high-quality product is also of utmost importance. To ensure effectiveness, I recommend using 100% organic ashwagandha, free of fillers, additives, and excipients.

Sources and References

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