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Home Sci-Tech

The Compound Psilocybin in Magic Mushroom Found Safe for Consumption in Largest Ever Controlled Study

by clnAdrian
December 22, 2019
in Sci-Tech, Science
Reading Time: 2 mins read
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The Compound Psilocybin in Magic Mushroom Found Safe for Consumption in Largest Ever Controlled Study
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By Andy Gregory | Independent

The largest controlled study of psilocybin – the psychoactive ingredient in magic mushrooms – has found the compound safe for human consumption, bringing researchers one step closer to developing a psilocybin-based treatment for depression.

Volunteers who received doses of the psychedelic compound experienced no serious adverse effects in phase one clinical trials at Kings College London (KCL).

Microdosing Psilocybin has been tipped as a potentially groundbreaking treatment for mental health disorders that could replace antidepressants, with some research suggesting it could also aid those dealing with addiction.

“The results of the study are clinically reassuring and support further development of psilocybin as a treatment for patients with mental health problems that haven’t improved with conventional therapy, such as treatment-resistant depression,” said KCL’s Dr. James Rucker, the study’s lead investigator.

Most of the minor adverse events recorded were of the expected psychedelic nature, researchers found, with changes to sensory perception and mood, but no negative effects on cognitive and emotional functioning.

The phase one trials – which sought to test the compound’s safety, not its therapeutic value – compared the effects of varying doses of the psilocybin-based drug COMP360 and placebos in 89 healthy volunteers.

There were 25 dosing sessions in total. In each session, six participants would receive either 10mg or 25mg doses or a placebo during a one-on-one session with a therapist lasting roughly six hours, with a follow-up period of 12 weeks.​

Research by the company behind the trial, Compass Pathways, into using psilocybin as a treatment for depression has been fast-tracked in the US, receiving special “breakthrough therapy” status from the Food and Drug Administration.

It is currently running phase two studies across Europe and North America involving 216 patients who suffer from depression that hasn’t responded to treatment.

“This study is part of our overall clinical development program in treatment-resistant depression,” Compass Pathways’ co-founder Dr. Ekaterina Malievskaia said.

READ THE REST OF THIS ARTICLE…

Tags: "featuredfeaturedmagic mushroommagic mushroom psilocybinpsilocybin mushroomspsilocybin researchpsilocybin study
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