Why Some People with Brain Markers of Alzheimer’s Have No Dementia

By Olga Zolochevska, et al | Science Daily

Summary:

A new study has uncovered why some people that have brain markers of Alzheimer's disease (AD) never develop the classic dementia that others do. The results showed that resilient individuals had a unique synaptic protein signature that set them apart from both demented AD patients and normal subjects with no AD pathology.

Full Story:

A new study from The University of Texas Medical Branch at Galveston has uncovered why some people that have brain markers of Alzheimer's never develop the classic dementia that others do. The study is now available in the Journal of Alzheimer's Disease.

Alzheimer's disease, the most common form of dementia, affects more than 5 million Americans. People suffering from Alzheimer's develop a buildup of two proteins that impair communications between nerve cells in the brain — plaques made of amyloid beta proteins and neurofibrillary tangles made of tau proteins.

Intriguingly, not all people with those signs of Alzheimer's show any cognitive decline during their lifetime. The question became, what sets these people apart from those with the same plaques and tangles that develop the signature dementia?

“In previous studies, we found that while the non-demented people with Alzheimer's neuropathology had amyloid plaques and neurofibrillary tangles just like the demented people did, the toxic amyloid beta and tau proteins did not accumulate at synapses, the point of communication between nerve cells,” said Giulio Taglialatela, director of the Mitchell Center for Neurodegenerative Diseases. “When nerve cells can't communicate because of the buildup of these toxic proteins that disrupt synapse, thought and memory become impaired. The next key question was then what makes the synapse of these resilient individuals capable of rejecting the dysfunctional binding of amyloid beta and tau?”

In order to answer this question, the researchers used high-throughput electrophoresis and mass spectrometry to analyze the protein composition of synapses isolated from frozen brain tissue donated by people who had participated in brain aging studies and received annual neurological and neuropsychological evaluations during their lifetime. The participants were divided into three groups — those with Alzheimer's dementia, those with Alzheimer's brain features but no signs of dementia and those without any evidence of Alzheimer's.

Source: University of Texas Medical Branch at Galveston

[Read more here]

Robert O’Leary, JD BARA, has had an abiding interest in alternative health products & modalities since the early 1970’s & he has seen how they have made people go from lacking health to vibrant health. He became an attorney, singer-songwriter, martial artist & father along the way and brings that experience to his practice as a BioAcoustic Soundhealth Practitioner, under the tutelage of the award-winning founder of BioAcoustic Biology, Sharry Edwards, whose Institute of BioAcoustic Biology has now been serving clients for 30 years with a non-invasive & safe integrative modality that supports the body’s ability to self-heal using the power of the human voice. Robert brings this modality to serve clients in Greater Springfield, Massachusetts and New England (USA) & “virtually” the world. He can also be reached at romayasoundhealthandbeauty@gmail.

 

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