What Causes Male Infertility? Sperm Cells With Poorly Packaged Genes, Researchers Say


By Susan Scutti | Medical Daily

male sperm 3-compressed

The human genome would span nearly six feet if unfurled, yet every cell in your body contains a complete copy. How does that work? The DNA wraps itself like thread around protein spools called histones, and these genes and proteins combined form a complex referred to as a chromatin. Yet sperm (a man’s reproductive cells) are much smaller than most cells, so early in their development, the histone spools are replaced by even tinier proteins called protamines. Now, researchers from Cold Spring Harbor Laboratory (CSHL) discovered that this moment of substitution — referred to as chromatin remodeling — is essential for male fertility, and when this process somehow goes awry, the result is infertility.

Finding out that you're infertile can be very difficult, but there are many different fertility clinics around the country. Fertility Plus offers a range of solutions such as IVF and embryo screening.

New Study Shows Pesticides Are A “Major Cause” of Infertility & Male Erectile Dysfunction

Male Infertility

When people think of fertility, they most often think of women, yet men play an equal role in fertility and may be the cause of childlessness. In fact, more than three million American men also experience infertility. Male infertility can be a temporary issue caused by a reaction to certain conditions, say, a sexually transmitted disease or even a tumor. On the other hand, infertility may be a permanent condition caused by a fundamental issue with the sperm itself, including too few sperm produced, misshapen sperm, motility (when sperm that cannot swim properly), or blockages that prevent sperm from joining with semen.

To better understand infertility, then, scientists commonly investigate sperm, the specialized cell that is so small 30 times more petite than the female egg — it contains little more than DNA and molecular motors. From head to tail, a sperm cell is invisible to the naked eye, just about 1/500th of an inch. For this reason, even more than other cells, DNA must be tightly packaged to fit within its miniscule boundaries.

Confirmed: Cell Phones Affect Male Fertility and Fracking Chemicals Are Linked To Infertility and Birth Defects.  

CSHL Professor Dr. Alea Mills and Dr. Wangzhi Li, lead author of a new study published Tuesday in Nature Communications, identified a role played in male infertility by Chd5, the protein that regulates chromatin remodeling, the moment when protamines replace histones.  The team discovered Chd5 as a potential cause of sterility when they analyzed data from testes biopsies obtained from men with sperm defects causing infertility. “We found that men with more severe defects had the lowest levels of Chd5,” Mills said.

Read the rest of the article…

Tags: , , , , , ,


If you enjoyed this article, subscribe now to receive more just like it.

Subscribe via RSS Feed Connect on YouTube

7 Reader Comments

Trackback URL Comments RSS Feed

  1. 758741024235285@facebook.com' Anthony Pero says:

    Why are you continually posting weird articles? The last few days have been a total let down of uplifting things that are usually posted. I’m going to have to unlike this page.

    • 858873907501587@facebook.com' Tupu King Agafili says:

      Well this is a lot more scientific than the sex positions it’s posted before :/ …

    • 1180318281994704@facebook.com' Jason Winter says:

      It’s all usually a distraction from the elephant in the room that no media or weather station will report on anyway~ geoengineering get informed get involved and have a nice day✨

    • 148270801883880@facebook.com' Conscious Life News says:

      Hey Anthony! We have some cool articles and posts coming your way for the rest of the week.

  2. 1154557757905723@facebook.com' Jose Esteves Castillo says:


  3. 1041986055813196@facebook.com' Okechukwu Lawrence says:

    junkie food

  4. 1180318281994704@facebook.com' Jason Winter says:

    Have you heard of nano particulates being disbursed with aerosol spraying into the atmosphere- worldwide! http://Www.geoengineeringwatch.org

Leave a Reply

Your email address will not be published.

This site uses Akismet to reduce spam. Learn how your comment data is processed.

FAIR USE NOTICE. Many of the articles on this site contain copyrighted material whose use has not been specifically authorized by the copyright owner. We are making this material available in an effort to advance the understanding of environmental issues, human rights, economic and political democracy, and issues of social justice. We believe this constitutes a 'fair use' of the copyrighted material as provided for in Section 107 of the US Copyright Law which contains a list of the various purposes for which the reproduction of a particular work may be considered fair, such as criticism, comment, news reporting, teaching, scholarship, and research. If you wish to use such copyrighted material for purposes of your own that go beyond 'fair use'...you must obtain permission from the copyright owner. And, if you are a copyright owner who wishes to have your content removed, let us know via the "Contact Us" link at the top of the site, and we will promptly remove it.

The information on this site is provided for educational and entertainment purposes only. It is not intended as a substitute for professional advice of any kind. Conscious Life News assumes no responsibility for the use or misuse of this material. Your use of this website indicates your agreement to these terms.

Paid advertising on Conscious Life News may not represent the views and opinions of this website and its contributors. No endorsement of products and services advertised is either expressed or implied.
Send this to a friend