Green Tea Ingredient May Target Protein To Kill Oral Cancer Cells

Written by on October 2, 2015 in Hazards, Issues & Diseases, Health with 9 Comments
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TeaA compound found in green tea may trigger a cycle that kills oral cancer cells while leaving healthy cells alone, according to Penn State food scientists. The research could lead to treatments for oral cancer, as well as other types of cancer.

Earlier studies had shown that epigallocatechin-3-gallate — EGCG — a compound found in green tea, killed oral cancer cells without harming normal cells, but researchers did not understand the reasons for its ability to target the cancer cells, said Joshua Lambert, associate professor of food science and co-director of Penn State's Center for Plant and Mushroom Foods for Health. The current study shows that EGCG may trigger a process in the mitochondria that leads to cell death.


“EGCG is doing something to damage the mitochondria and that mitochondrial damage sets up a cycle causing more damage and it spirals out, until the cell undergoes programmed cell death,” said Lambert. “It looks like EGCG causes the formation of reactive oxygen species in cancer cells, which damages the mitochondria, and the mitochondria responds by making more reactive oxygen species.”

As this mitochondrial demise continues, the cancer cell also reduces the expression of anti-oxidant genes, further lowering its defenses.
“So, it's turning off its mechanism of protection at the same time that EGCG is causing this oxidative stress,” Lambert added. –

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9 Reader Comments

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  1. 10205107704632402@facebook.com' Donna M. Tobin says:

    Jess Crouch

  2. 984546181588812@facebook.com' Esther Watson says:

    That’s all well and good but what CAUSES the cancer in the first place. Surely by finding the cause the cure would be easier to find.

  3. 149943568688808@facebook.com' Karim Hoque says:

    Green tea Better for Health

  4. 1123136087713767@facebook.com' Ivan A Hernandez says:

    David Silvey

  5. 1123136087713767@facebook.com' Ivan A Hernandez says:

    Rene Vela Jr.

  6. 10153257310439735@facebook.com' Mark W. Mitchell says:

    Magic.

  7. 1051559168212369@facebook.com' Jeffrey King Kawasaki Peck says:

    Makes sense

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