Genetically Modified Humans Are Coming: U.S. Scientists Just Backed Permanent Gene Editing

Posted by on February 17, 2017 in Sci-Tech, Science with 0 Comments

By Kalee Brown | Collective Evolution

“Genetically modified humans” sounds like a term that belongs in Hollywood, but it’s actually a very real possibility, and one that’s being heavily discussed in the scientific community. Contributing to one of the most controversial topics to date, a panel of science experts in the U.S. just examined and gave their support for germline editing. This means that in the future, parents will likely be able to tamper with the genetics of their children pre-birth.

Germinal choice technology refers to reprogenetic technologies that enable parents to alter the genetic constitutions of their children. One of the ways this can be done is through germline editing, which is a fancier term for human genetic engineering. Germline editing alters the genes of a sperm or an egg, but it then changes the future DNA of every single cell in the embryo. This means that the genetic changes made to the embryos will then affect all future generations within that family lineage.


Germline Editing Will Likely Be an Option in the Future

The panels were made up of experts from two of the most prestigious scientific institutions in the U.S., both of which recommended that germline editing be viewed as a serious option in the future and not be prohibited outright (source).

This is a dramatically different stance than the last assessment given in December 2015 by an international summit of scientists, who stated that it would be “irresponsible to proceed” with germline editing given the controversy surrounding the subject and the safety issues involved, all of which have yet to be resolved.

The panels’ discussions can be further analyzed in a report released earlier this week by the U.S. National Academy of Sciences and the National Academy of Medicine. The panel recommended that germline editing of early embryos, eggs, or sperm should only be permitted to prevent serious disease or disability if there’s significant scientific evidence illustrating that the procedures are safe.

Related Article: Scientists and Activists Call for Ban on Human Gene Editing

“Human genome editing holds tremendous promise for understanding, treating, or preventing many devastating genetic diseases, and for improving treatment of many other illnesses. . . . However, genome editing to enhance traits or abilities beyond ordinary health raises concerns about whether the benefits can outweigh the risks, and about fairness if available only to some people,” explained Alta Charo, co-chair of the study committee and Sheldon B. Lubar Distinguished Chair and Warren P. Knowles Professor of Law and Bioethics, University of Wisconsin-Madison.

One of the illnesses the panel specifically mentioned that germline editing could be used to prevent is Huntington’s disease, a progressive brain disorder that can result in uncontrollable movement, emotional issues, and loss in cognition, most commonly appearing in a person’s thirties or forties. However, the panel was quick to note that with these alterations could come some very serious side effects.

One of the potential risks includes developing new conditions, diseases, or mutations. If this happened, parents would have no idea until their babies are born and begin to mature.

Perhaps the most obvious risk is the societal implications associated with the genetic engineering of humans. If it’s an expensive process, meaning it will likely only be made available to upper class citizens who can afford it, it could create a “designer class” of babies with preferred qualities and genes.

“These kinds of scenarios used to be science fiction; they used to be seen as far-off hypotheticals… But actually, right now, I think they’re urgent social justice questions,” said biotechnologist Marcy Darnovsky from the Center for Genetics and Society to Rob Stein at NPR.

“[W]e’re going to be creating a world in which the already privileged and affluent can use these high-tech procedures to make children [with] biological advantages,” she continued. “And the scenario that plays out is not a pretty one.”

“Previously, it was easy for people to say, ‘This isn’t possible, so we don’t have to think about it much,’ ” said MIT researcher Richard Hynes, who helped lead the committee, to The New York Times. “Now we can see a path whereby we might be able to do it, so we have to think about how to make sure it’s used only for the right things and not for the wrong things.”

Will Genetic Engineering Mark the Birth of Transhumanism?

Transhumanism is a futuristic ideology which purports that humans will be altered and improved using sophisticated technologies in the future to upgrade our intellectual, physical, and mental capabilities. Many scientists are actually in favour of this, especially as we become more technologically advanced, making this seem more realistic.

Elon Musk supports this movement, in fact, as he believes that human beings will eventually use technology to enhance our inherent natural capabilities.

“Over time we will see a closer merger of biological intelligence and digital intelligence. It is all about the band width of the brain,” Musk said.

“Some high band width interface to the brain will be something which helps achieve symbiosis between human and machine intelligence, which solves a control and usefulness problem,” he continued.

Related Article: British Scientist Plans to Genetically Modify Human Embryos After Ethics Committee’s Approval

Musk has spoken about this topic on several occasions. For example, last year he explained that we should consider getting brain implants in the future because, without them, we may not be able to compete with artificial intelligence (AI). He also has strong opinions about AI, arguing it could pose a threat to us if we become too dependent on it (source).

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